My research work consists in understanding how microenvironmental cues influence, guide and shape cell-cell contacts. We are currently particularly interested in determining the role of the biophysical environment in the establishment of apico-basal polarity in mammary gland cells and in liver cells.

Combining topographical cues and biochemical cues at cell aggregate level by addition of a micro-pillars base layer. Patient-derived head and neck cancer cell aggregates (HN cells) were grown into 60 µm diameter and 30 µm height micro-niches with Laminin (green) homogeneously coated on the pit walls, and fibronectin (red) coated on the NOA 73 micro-pillars (2 µm height and diameter).

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Custom micropatterning for cell control.
With PRIMO, you can design your own micropatterning experiments, both in 2D and 3D.

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