Alvéole - Take care of your cells


Conferences, Workshops,
Press coverage, Press releases…

Last news

September 28, 2017


Combining topographical cues and biochemical cues at cell aggregate level by addition of a micro-pillars base layer. Patient-derived head and neck cancer cell aggregates (HN cells) were grown into 60 µm diameter and 30 µm height micro-niches with Laminin (green) homogeneously coated on the pit walls, and fibronectin (red) coated on the NOA 73 micro-pillars (2 m height and diameter).

"My research work consists in understanding how microenvironmental cues influence, guide and shape cell-cell contacts. We are currently particularly interested in determining the role of the biophysical environment in the establishment of apico-basal polarity in mammary gland cells and in liver cells. The use of PRIMO in this context proved absolutely essential since it allowed us to create artificial microniches in 3D where we could control up to 150 combinations of environmental cues.

By printing our protein of choice and microfabricating intricate structures under the microscope, we are gradually uncovering how the geometrical and biophysical parameters drive the elongation of lumen into tubes in the context of hepatic development and diseases.

PRIMO is unique in its capabilities, and for us it is the perfect tool. Submicron-resolution, flexibility and versatility in terms of the proteins you can deal with. It is a very reliable tool to print proteins on surface. I know that additional capabilities are on the way too."

says Pr. Virgile Viasnoff, Associate Professor at MechanoBiology Institute - National University of Singapore, and Director of Research at CNRS

September 26, 2017

PRIMO LOAN AT FORSCHUNGSZENTRUM JULICH: The team of Pr. Rudolf Merkel from Institute of Complex Systems Biomechanics (ICS-7) at Forschungszentrum Jülich enjoying their first self-made protein micropattern with PRIMO!

September 18, 2017

NEW VIDEO TUTORIALS ON OUR « SUPPORT » WEBPAGE: Get more details on all the key steps of photopatterning with PRIMO: from drawing your micropatterns to seeding cells on it, plus all technical aspects such as switching on and calibrating the system, or preparing your substrates with an antifouling coating!

September 12, 2017

PRIMO AT THE INSTITUTE FOR BIOENGINEERING OF CATALONIA: Now in Xavier Trepat’s lab! Here is Raimon Sunyer Borrell starting using Leonardo software which controls PRIMO photopatterning system! We are looking forward to seeing your micropatterning experiments conducted with PRIMO.

September 11, 2017

MICROPATTERNING AND FOCAL ADHESION: Epithelial cells plated on a grid micropatterned with PRIMO: Actin (green), focal adhesions (red) and nuclear enveloppe (blue).

September 5, 2017

MULTIWELL PDMS STENCILS BY ALVEOLE: We are glad to announce that we are officially launching the multi-well PDMS Stencils. We have developed this new product in order to facilitate the PRIMO photopatterning experimental manipulations of our users. It allows to:

- reduce the volume of reagents used per experiment,

- use different experimental conditions on a single substrate,

- confine the liquid and prevent it from spreading on the microscope objective,

- and makes it easy to localize the patterned area.

August 28, 2017

PRIMO AT THE UNIVERSITY OF TWENTE: Verena Schwach from Robert Passier’s lab at the University of Twente is preparing her experiments of micropatterning of cardiomyocytes on glass. We are looking forward to discovering her results.

August 21, 2017

MICROMETRIC ECLIPSE: We witnessed a micrometric solar eclipse over France before the real one happened in the USA! Scale bar = 50µm

August 16, 2017

NO LIMITS TO YOUR PATTERNS: Pattern of the day done with PRIMO, Eiffel Tower in Fibronectin and then with MDCK cells.

August 2, 2017

PRIMO NOW AT THE NORTHEASTERN UNIVERSITY: Niccole Schaible and Sam Pillot from the Northeastern University - Department of Bioengineering - now have a PRIMO! They are using it to study cardiomyocytes on PDMS with direct photopatterning and cell-cell interaction on polyacrylamide gel doing micropatterning transfer.

July 27, 2017

AlVEOLE HAS MOVED: Here is our new address: 30 rue Campo-Formio, 75013 Paris, France. More space for continuing our expansion and bigger labs for even better experiments! Discover it for yourself with this time-lapse video.

July 26, 2017

LECTURE ON PRIMO AT STANFORD: We have been invited to present PRIMO at the Stanford University during the Mechanobiology and Biofabrication Methods workshop BIOPHYS 342A. Here is Matthieu Opitz from our R&D team giving a lecture on PRIMO! During the workshop PRIMO was used for experiments on cell adhesion and migration, with protein gradients and patterning on polyacrylamide gel.

July 13, 2017

PRIMO IS AT STANFORD: Proud to have installed a PRIMO at Stanford University! Gaspard Pardon can now start experimenting with it to micropattern proteins on hydrogels in 3D, multi-protein patterning and many other projects!

July 12, 2017

PATTERNING IS ART: Thibaut Brunet shared on Twitter a picture of cells plated on micropatterns he generated with PRIMO, during the Physiology summer course at the Marine Biological Laboratory (MBL). Imaged by Nikon USA.

…Find all our previous news on

Conferences and Workshops

If you too are attending the following events, take this opportunity to meet our team. We will be glad to present you the PRIMO photopatterning technology and discuss your application projects with you!

September 14 - 19, 2017

USA, Bethesda MD - We will be at the NIH Research Festival Exhibit

October 2 - 5, 2017

Australia, Adelaide - GeneWorks our distributor in Australia will be representing us at the ComBio Adelaide meeting

October 11 - 13, 2017

Germany, Saarbrücken - Come and meet us at the Cell Physics 2017 meeting

October 17 - 18, 2017

United Kingdom, Cambridge - Visit our booth at the Bioprinting & 3D Printing in the Life Sciences Europe Meeting

December 3 - 5, 2017

USA, Philadelphia (PA) - BOOTH 539 Don’t miss our in-booth talks and demos at the ASCB / EMBO 2017 Meeting

Press Coverage

04.10.2017, Labiotech

Creating Miniature Homes for Cells

01.04.2017, The Magazine of the Australian Society for Biochemistry and Molecular Biology

GeneWorks distributes PRIMO

24.12.2016, Spectra Analyse

PRIMO ou le photopatterning de motifs en protéines

20.12.2016, Biospace

Alveole Appoints GeneWorks As Its Exclusive Distributor In Australia

11.11.2016, Biospace

Alveole presents its new PRIMO photopatterning technology at American Society for Cell Biology 2016

02.11.2016, Laboratorio 2000

Controllo del microambiente cellulare

01.08.2016, Genetic Engineering & Biotechnology News

Customized Control of the Cell Microenvironment

21.07.2016, CNRS

Alvéole : pour un contrôle sur mesure du microenvironnement cellulaire

16.07.2016, L’usine nouvelle

Quattrocento lève 5,2 millions d’euros pour développer des medtechs

28.06.2016, IINS

PRIMO, a new device for creating photopatterns for cellular assays

27.06.2016, Cadureso

PRIMO : le contrôle sur mesure du microenvironnement cellulaire

27.06.2016, Biospace

PRIMO: Offering Customized Control Of The Cell Microenvironment

27.06.2016, Teknoscienze Publisher

PRIMO: offering customized control of the cell microenvironment

27.05.2016, Biotech Info

Alvéole, une ruche d’innovation

02.04.2016, DDNews – pharma, biotech & life science

New Product Awards

Press releases

Download our press releases and images. If you have any questions, please do not hesitate to contact Marie-Charlotte Manus.

20 December 2016

Alvéole appoints GeneWorks as its exclusive Distributor in Australia. Download the press release in pdf format.

10 November 2016

Alvéole presents its new PRIMO photo‐patterning technology at ASCB 2016. Download the press release in pdf format.

27 June 2016

PRIMO: offering customized control of the cell microenvironment. Download the press release in pdf format.


PRIMO and PLPP. Download the zip file with all HD images.