Microfabrication of microstructured substrates

With PRIMO photopatterning technology, create your microstructured substrates with all the geometries and topographies you can imagine, including micro-pillars, micro-wells or grooves.

Use PRIMO to structure photosensitive resins and create reusable molds on which you can polymerize your favorite material, and thus create your own microstructured substrates.

And to go even further, you can then micropattern biomolecules on your substrates to combine biochemical and topographic control.

photolithography-microfabrication — Micro-pillars of 5 µm diameter spaced by 5 µm made by the replica molding of a primary SU8 photoresist master obtained by photolithography with PRIMO.

sequential-photopatterning — Sequential photopatterning of Fibrinogen-A488 in green and Protein A-A647 in red onto PDMS micro-pillars microfabricated with PRIMO.

PEG-biotin successively photopolymerized with PRIMO — PEG-DA mixed with PEG-FITC (green), PEG-TRITC (blue) or PEG-biotin successively photopolymerized with PRIMO. Streptavidin incubated afterward specifically stains the outer surface of the PEG-biotin hydrogel (red). Courtesy of C. Stoecklin and V. Viasnoff

Do you have a question about your project of experiment with PRIMO?

Our research and application development team can help you set up or optimize your experimental protocols!

Dynamic control of cell migration

Spheroid formation

Cell confinement

Dynamic control of cell migration

Spheroid formation

Cell confinement

Controlling
the cellular
microenvironment

Alvéole has developed innovative solutions adapted to all standard cell culture substrates, rigid or soft, in 2D or 3D.

Resource Center

Our team gives you all its tips you need to carry out your experimental manipulations and go even further!

Testimonials

Our users describe their research projects and explain why they chose to use PRIMO!

Read the testimonials