BOOTH 1019

This year again, Alvéole is thrilled to attend the ASCB EMBO 2018 annual meeting and present PRIMO bioengineering system for creating custom in vitro cell microenvironments:

  • Microfabrication: controlled topography
  • Hydrogel microstructuration: stiffness
  • Functionalization: controlled biochemistry

Better study living cells!

Win a free customized patterned glass substrate

Come by our booth and present us your project of experiment: we will offer a free customized patterned glass substrate, to a limited number of participants.

Live demos and in-booth talks

Don’t miss our daily in-booth talks and live demos at ASCB EMBO 2018. See for yourself how PRIMO works and learn more about the applications such as controlling the cell adhesion, cell migration, cell confinement.

Sunday 9 December: 1:00pm – 1:30pm, with Dr. Robert Fischer – NIH
Monday 10 December: 1:30pm – 2:00pm, with Dr. Vijaykrishna Raghunathan – University of Houston
Tuesday 11 December: 2:00pm – 2:30pm

Tech Talk and Discussion

Sunday 9 December, 3:00pm – 4:00pm / Theater 1

Fine-tuning the mechanical and biochemical properties of in vitro microenvironments with a versatile and contactless photopatterning technology: PRIMO


In vivo, the cellular microenvironment has a crucial impact on the regulation of cell behavior and functions such as cellular differentiation, proliferation and migration. One of the challenges confronting cell biologists is to mimic this microenvironment in vitro to more efficiently study living cells and model diseases. Here we present PRIMO®: a versatile, contactless and maskless UV projection system, which allows to engineer custom in vitro microenvironments and fine-tune their topography and biochemistry in a highly flexible and reproducible manner.

We will first show that the projected UV light can be used in order to structure cell cuture substrates via photopolymerization of: (a) photosensitive resists to create molds onto which elastomeric solutions can be polymerized (microfabrication), (b) and of the most commonly used hydrogels (microstructuration). Then we will show that PRIMO® is a suitable tool to print biomolecules on all cell culture substrates (including glass, plastic, soft or stiff substrates, textured surfaces, etc.) with an exquisite control over protein densities (micropatterning).

Some of our users will then share their research works conducted with PRIMO, in cell biology and microfluidics, from sub-cellular to cell population levels: reconstitution of the cytoskeleton with purified proteins, focal adhesions, cytoskeleton organization, force measurement, single cell confinement in 3D, cell migration, tissue engineering, spheroid formation, etc.

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