Control the chemistry and topography of the cell microenvironment and study their impacts on cell development using an innovative quantitative multi-protein photopatterning solution.

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Unrivalled performance



gray levels



depending on
experimental conditions

High Resolution


over the entire field of view*

*Approximately 500×300µm,
20x objective



for a full field pattern*

*Approximately 500×300µm,
20x objective



for cell culture**

** slides, coverslips, Petri dishes,
3D devices, microfluidic devices, etc.

PRIMO platform

Innovative photopatterning technology

Micropatterning made easy

Discover the key steps of PRIMO photopatterning process

Pattern design


Pattern design

An image file is loaded in
Leonardo Software which sends it
to the PRIMO module

Illumination UV


UV illumination

PRIMO projects the image
onto the substrate (UV light, λ=375nm).
The pattern results from the
combined action of UV and PLPP
(photoactivatable reagent).



Protein micropatterning

Proteins are added
(fibronectin for example) and bind to
the illuminated areas only.



Cell adhesion

Cells are seeded
and adhere to the
protein micropatterns only.

Controlling the microenvironment

To mimic and control the cellular microenvironment in vitro, Alvéole has developed innovative solutions adapted to all standard cell culture substrates, rigid or soft,
in 2D or 3D.

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Award-winning projects

SLAS: PRIMO elected best 2016 product

SLAS: PRIMO elected best 2016 product

SLAS (Society for Laboratory Automation and Screening) is a worldwide community with over 30,000 university and industrial scientists who all target the optimization that potential technologies have in the progress of research work. There were 320 exhibitors in the 2016 edition of the SLAS conference that took place in San Diego. During this event, new products were assessed for their innovative advantages and impacts in the field of laboratory techniques. PRIMO was chosen as the best product in 2016.

The Paris Grands Prix de l’Innovation (Innovation Trophies): 2017 Finalist

The Paris Grands Prix de l’Innovation (Innovation Trophies): 2017 Finalist

Alvéole was selected as a finalist in the Health section of the City of Paris Innovation Trophies. The goal of this contest is to support and reward innovative Parisian companies in quickly growing fields, which develop the economy in Greater Paris. Since it was founded, the Innovation Trophies have awarded 67 prizes to over 3,200 candidates. The 2017 Awards Ceremony will be held on December 12 in Paris.

The 2014 Worldwide Innovation Contest: Alvéole comes in first place

The 2014 Worldwide Innovation Contest: Alvéole comes in first place

Alvéole was the winner of the Worldwide Innovation Contest for its CellForLife project in the individual medicine category. This ambitious project proposes a complete offer with a manipulation platform and a miniaturized device to control stem cell differentiation, in order to devise personalized treatments for patients suffering from genetic diseases. In the framework of their work on Rett syndrome, researchers from the Cochin Institute used tools made by Alvéole to understand this pathology and develop targeted therapies.

Our users

See all the academic laboratories that have chosen to use PRIMO for their research work.

Discover our customers’ testimonials



Resources and Support

Our team gives you all the tips you need to successfully conduct
your experimental projects and go even further!




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Discover Alvéole

Alvéole was founded in 2010 by three researchers from CNRS in collaboration with Quattrocento, a “creator of companies” in the life sciences field.

Learn more about Alvéole

Job opportunities

Alvéole is recruiting. Are discoveries, innovations and science a genuine passion for you? It’s the same for us.
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