“Controlling the topography and biochemistry of cell culture substrates with PRIMO”
One of the challenges confronting cell biologists is to mimic the micro-environment in vitro to more efficiently study living cells. (…) PRIMO allows to tailor cell microenvironment topography via microfabrication and biochemistry via micropatterning…
Read the application note
When you offer cells a choice… Yes they go for the higher protein density! Experiment conducted by Pau Guillamat from Aurelien Roux’ lab – University of Geneva.
Watch the video of cells migrating towards two different protein densities in Pau Guillamat’s testimonial.
Meet us on Booth 8, ask us all your questions and see how PRIMO custom micropatterning system can help you tune the cell microenvironment chemistry and topography. And thus precisely control cell development and proliferation !
Special thanks to the team of the Laboratory of Structural Biophysics & Mechanobiology, Gregory M. Alushin PhD, The Rockefeller University, for sending us this picture of them photopatterned with PRIMO custom photopatterning system!
We look forward to seeing your experiment results with PRIMO, studying the cytoskeleton!
Virgile Viasnoff‘s lab at the Mechanobiology Institute – National University of Singapore is going further in controlling cell microenvironment in 3D: with micro-niches in which they control chemical, topographical and rheological cues using PRIMO photopatterning system!
Read their Paper.
See how Jorge Ferreira form i3S, Universidade do Porto used PRIMO custom micropatterning technology to control cellular geometry and impose spatial constraints during mitotic progression.
And read his feedback on PRIMO technology.
New scientific paper in which PRIMO was used: In situ photo-patterning of pressure-resistant hydrogel membranes with controlled permeabilities in PEGDA microfluidic channels, Lab Chip, 2018, Advance Article, Jérémy Decock, Mathias Schlenkb and Jean-Baptiste Salmon.
Read it here
List of papers using PRIMO here
Meet us on Booth 319 and learn more about PRIMO applications in cell biology by attending our exhibitor presentation with some of our users as special guests on Sunday, February 18 – 12:30pm – Room 6!
Find the programme of the presentation here.
Nandor Roczo from GeneWorks – our Australien Distributor – presents PRIMO with a poster at the Lorne Cancer 2018 conference from 8 to 10 February. Don’t miss it!
PRIMO and Leonardo installation/training last week at Cell Adhesion & Mechanics lab, Institut Jacques Monod: CNRS Research Directors Benoit Ladoux and René-Marc Mège, and PhD candidate Estelle Gauquelin seem to have enjoyed it, and so did we!
Jakub Pospíšil – PhD student in Dr. Josef Jaros Department of Histology & Embryology at Faculty of Medicine, Masarykova univerzita – working on his first pattern with PRIMO custom micropatterning for cell control and the new version of Leonardo Photopatterning software.
The new version of Leonardo software is now available! Discover it on our dedicated webpage!
In addition to the replication, rotation, alignment, grayscale images management features, you can now define ROIs, program complex experimental sequences and map your samples!
Pau Guillamat, Postdoctoral Fellow at Université de Genève Biochemistry department in Aurélien Roux’ Research Group, is testing PRIMO micropatterning solution and Leonardo software. We’re looking forward to discovering the results!
ASCB EMBO 2017 conference official pictures are online. Here Manuel Théry during our in-booth demo.
We are looking forward to attending the ASCB annual meeting again this year and meeting many more interesting people!
Alvéole team wishes you a Happy New Year!
Take some time to reflect on 2017 and then start thinking about new projects for 2018! Looking back on some of our users’ applications PRIMO helped to carry out…
Les Echos journal presents the technologies and companies emerging from Bordeaux University Neurosciences Institute, among which you find Alvéole and its custom micropatterning technology.
Read full article (Fr only) on their website.
The Scientist shares one of our experiment which shows how PRIMO micropatterning system allows to study cell migration with a custom micropattern that controls cell microenvironment!
Read the full article on their website
2D-STORM image by Abbelight of patterned epithelial cells labelled for Actin on square micropatterns done with PRIMO.
Jorge Ferreira (Group leader) and Vanessa Nunes (PHD Student) are testing PRIMO and starting to use it on their own. Here is there first test: photopolymerization of photocurable material shaped in the i3S logo.
Alvéole was selected as a finalist in the Health section of the City of Paris Innovation Trophies. The goal of this contest is to support and reward innovative Parisian companies in quickly growing fields, which develop the economy in Greater Paris. The 2017 Awards Ceremony will be held on December 12 in Paris.
Labiotech explains the importance of controlling the microenvironment in order to better study living cells in vitro. They highlight the micropatterning and how PRIMO can make a difference for cell biology researchers.
Read the full article on their website
The CytomorphoLab team imaged a beautiful video of acto-myosin contraction on a micropattern shaped as our logo and done with PRIMO. Courtesy of Manuel Théry, Laurent Blanchoin, Christophe Guérin, Dmitry Ayollo et Benoit Vianay.
Watch the video
The use of PRIMO in this context proved absolutely essential since it allowed us to create artiﬁcial microniches in 3D
where we could control up to 150 combinations of environ-mental cues.
The team of Pr. Rudolf Merkel from Institute of Complex Systems Biomechanics (ICS-7) at Forschungszentrum Jülich enjoying their first self-made protein micropattern with PRIMO!
Get more details on all the key steps of photopatterning with PRIMO: from drawing your micropatterns to seeding cells on it, plus all technical aspects such as switching on and calibrating the system, or preparing your substrates with an antifouling coating!
Now in Xavier Trepat’s lab! Here is Raimon Sunyer Borrell starting using Leonardo software which controls PRIMO photopatterning system! We are looking forward to seeing your micropatterning experiments conducted with PRIMO.
Epithelial cells plated on a grid micropatterned with PRIMO: Actin (green), focal adhesions (red) and nuclear enveloppe (blue).
We are glad to announce that we are officially launching the multi-well PDMS Stencils. We have developed this new product in order to facilitate the PRIMO photopatterning experimental manipulations of our users.
Watch the video
Verena Schwach from Robert Passier’s lab at the University of Twente is preparing her experiments of micropatterning of cardiomyocytes on glass. We are looking forward to discovering her results.
We witnessed a micrometric solar eclipse over France before the real one happened in the USA! Scale bar = 50µm
Pattern of the day done with PRIMO, Eiffel Tower in Fibronectin and then with MDCK cells.
Niccole Schaible and Sam Polio from the Northeastern University – Department of Bioengineering – now have a PRIMO! They are using it to study cardiomyocytes on PDMS with direct photopatterning and cell-cell interaction on polyacrylamide gel doing micropatterning transfer.
Here is our new address: 30 rue Campo-Formio, 75013 Paris, France. More space for continuing our expansion and bigger labs for even better experiments! Discover it for yourself with this time-lapse video.
Proud to have installed a PRIMO at Stanford University! Gaspard Pardon can now start experimenting with it to micropattern proteins on hydrogels in 3D, multi-protein patterning and many other projects!
Thibaut Brunet shared on Twitter a picture of cells plated on micropatterns he generated with PRIMO, during the Physiology summer course at the Marine Biological Laboratory (MBL). Imaged by Nikon USA.
Read the full article by The Magazine of the Australian Society for Biochemistry and Molecular Biology
Read the full article by Spectra Analyse.
Read the full article by Biospace.
Read the full article by Biospace.
Read the full article by Laboratorio 2000.
Read the full article by Genetic Engineering & Biotechnology News
Read the full article by CNRS Innovation
Read the full article by L’Usine Nouvelle.
Read the full article by IINS.
Read the full article by Biospace
Read the full article by Teknoscienze Publisher.
Read the full article by Cadureso.
Read the full article by Biotech Info.
Custom micropatterning for cell control.
With PRIMO, you can design your own micropatterning experiments, both in 2D and 3D.
Check the list of events we are attending or organizing. We will be glad to present you the PRIMO custom micropatterning technology and discuss your application projects with you!