The challenge of in vitro cell microenvironment

In vivo, the cellular microenvironment has a crucial impact on the regulation of cell behavior and functions such as cellular differentiation, proliferation and migration. However, its biochemical and structural complexity limits our understanding of the key parameters regulating cell behavior.

In vitro, one of the challenges confronting cell biologists is therefore to work with controlled and reproducible microenvironments to more efficiently study living cells and model diseases.

PRIMO bioengineering: flexibility to set and optimize in vitro conditions as you want

The PRIMO bioengineering technology relies on a contactless and maskless photopatterning module (PRIMO) and a dedicated software (Leonardo). The platform can be used to structure cell culture substrates through photopolymerization and to functionalize any cell culture substrate surfaces (stiff or soft, flat or microstructured) through micropatterning.

Bioengineering made easy

Discover the key steps of PRIMO photopatterning process


01 Pattern

Substrate structuration

02 Substrate

Substrate functionalization

03 Surface

Result: bettercell experiments

04 Result: better
cell experiments

PRIMO bioengineering technology: full workflow in video