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Fields of application

Adjust the biochemical and mechanical cues of the cell microenvironment in vitro with PRIMO and generate more physiologically-relevant cell models.

The system allows you to better study the behavior and development of living cells in a broad range of applications, such as: cytoskeleton dynamics, cell adhesion force measurement, cell confinement, cell migration, tissue engineering, spheroids.


Micropatterning

Micropatterning

Workflow principle
Intra-cellular mechanisms
Tune pattern geometries to impose different cell shapes to study intracellular cytoskeleton organization
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Neurons and Guidance
Conduct axon guidance experiments and study neurons in conditions as close as possible to their in vivo state.
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Cell migration
Easily induce and study cell migration by quickly creating any adhesive shape. Standardize studies on collective or individual cell migration.
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Disease modeling
Tune complex microenvironment with 2.5D topographies and diverse cell populations in order to obtain reproducible disease models.
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Cell force measurements
Create more reproducible models to mimic physiological or pathological cell forces.
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Cell behavior on topological cues
Control micropatterning alignment on existing topographies of cell culture substrates to study cell behavior on topological environments.
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Cell positioning for Cryo-ET
Create perfect sample for FIB-milling and electron Cryo-tomography by directly controlling cell adhesion, localization and shape.
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Microfabrication

Microfabrication

Workflow principle
Organ-on-a-chip production
Prototype your whole organ-on-a-chip in a record time and with a high reproducibility.
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Grayscale photolithography
Microfabricate complex structures like ramps and stairs with projection of gray levels.
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Microstructured substrate
Create your microstructured substrates with all the geometries and topographies you can imagine, including micropillars, microwells or grooves.
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Combining approaches
Control the cell microenvironment from the biophysical properties of the substrate to the biochemical parameters to create complex and relevant models.
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Hydrogel structuration

Hydrogel structuration

Workflow principle
3D Cell Culture
Polymerize photosensitive hydrogels to create structured substrates for your 3D cell culture models.
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Spheroids and organoids microwells
Grow reproducible 3D cell aggregates, control their shape, and organize them in space for a precise automated data analysis.
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Microfluidic chips in situ photopolymerization
Structure UV sensitive hydrogels inside microchannels.
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Functionalization of hydrogels
Combine protein micropatterning and hydrogel polymerization to turn common hydrogels into topographically and chemically heterogeneous environments.
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