Bioengineering custom cell microenvironments with PRIMO versatile and contactless photopatterning
- Dr. Manuel Théry, Research Director, CEA in Hospital Saint Louis, Paris
- Dr. Harikrishnan Parameswaran, Assistant Professor, Northeastern University
One of the challenges confronting cell biologists is to work with controlled and reproducible microenvironments in vitro to more efficiently study living cells and model diseases. This webinar presents a versatile and contactless photopatterning system, PRIMO, that allows researchers to engineer custom in vitro microenvironments and fine-tune their mechanical (microfabrication with photoresist, microstructuration of hydrogels) and biochemical properties (protein micropatterning), at the micrometer scale with high flexibility and reproducibility.
The speakers will show how this technology opens new possibilities for a large range of applications from sub-cellular to multi-cellular level: cytoskeleton organization, focal adhesions, cell migration, stem cell differentiation, single cell confinement in microwells, tissue engineering, drug testing, disease modelling – with a focus on asthma and the use of extracellular matrix micropatterning to study force transmission in a two-cell ensemble of human airway smooth muscle cells.
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