PRIMO 405

Bioprinting for 3D cell culture

Primo 405 is Alvéole’s new bioprinter optimized for precise cell embedding in various hydrogels. Its 405nm cell-friendly wavelength preserves viability while giving you full creative control over micro-environments. Primo 405 is ideal for tissue engineering, enabling organ and disease modeling with unparalleled resolution.


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In-well printing

Direct in-well printing up to 384-well plate format.

Gentle to cells

405 nm light preserves cell viability

Unmachted Resolution

Achieve patterns with 5 µm resolution

User-friendly

Very easy to use & flexible pattern design

Unrivalled performance

Labware compatibility

Any dish or plate format

up to 384 wells, organ-on-chip and microfluidic chips

Resolution

5 µm

depending on sample height

Speed

A couple of sec

per illumination field*

*Approximately 2500×1500µm,
4x objective

Gradients

256

gray levels

Material compatibility

Methylacrylated hydrogels

GelMA, PEGDA etc.

Supported files

 

.TIF .PNG .PDF

Easy  3-step process

 A straightforward & easy workflow from an idea to results

 Pattern design

Process-1

 Structure polymerization

Process 2

Cell culture

Process-3

Applications

Primo 405: detailed patterns in various hydrogels & precise structures with or without embedded cells.

Without cells

Hydrogel structures of several sizes from 60 µm to 7.5 µm lines Courtesy of LAAS, ©Tessella Biosciences
Hydrogel structures of several sizes from 60 µm to 7.5 µm lines Courtesy of LAAS, ©Tessella Biosciences

With cells

Left figures: Digital patterns used to photopolymerize EPC*-embedded constructs shown immediately after fabrication and after 2 days. Right figurse: Self-organizing photopolymerized EPCs after 7-day culture Mazari-Arrighi et al, 2024

PRIMO bioprinting technology

All-in-one platform easing the system installation!

 

The PRIMO Optical Platform is a ready-to-use integrated optical solution that simplifies access to Primo technology. With pre-integrated optics, users can quickly implement the PRIMO system without the need for a dedicated microscope. Available in two configurations, the platform delivers all PRIMO functionalities allowing bioprinting tailored to the evolving needs of research laboratories.

 

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